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Viagra and Cialis: what's better?

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Viagra and Cialis: what's better?

Postby Apotker on Thu Oct 29, 2009 8:50 am

Viagra or Cialis

At present, prevention and treatment of erectile dysfunction (impotence - the old terminology) is the most widespread use is made of such medications as Viagra (active ingredient - sildenafil citrate, brand pharmaceutical company Pfizer) and Cialis (active substance - tadalafil, the joint development of the pharmaceutical giant Eli Lilly and corporations "YCOS").
The first of Russia's pharmaceutical market Viagra appeared long ago in 1998, Cialis same - only in 2003.

The mechanism of action of both drugs are similar and by blocking the enzyme phosphodiesterase 5-th type (PDE-5), which in turn cleaves the enzyme cyclic guanosine monophosphate, responsible for the vascular component of the erection of the penis. In men with erectile dysfunction, reduced levels of cyclic guanosine monophosphate and always sufficient to ensure a full erection.
In order to improve the content of cyclic guanosine monophosphate to a level sufficient for erection, was used a simple but nevertheless long been non-obvious method, by blocking the enzyme that breaks down cyclic guanosine monophosphate.

Data on the pharmacokinetics of drugs Viagra and Cialis indicate greater effectiveness of the latter. First, the half-life Sildenafil shorter and is just 3-5 hours depending of the dose, while in tadalafil - 17,5 hours. Secondly, while maintaining an efficient activity and achieving an erection for Viagra is an average of 4 hours to Cialis - 24-36 hours.

As for side effects of Viagra and Cialis - they are similar in appearance and consist of dizziness, headache, diarrhea, nausea, nasal congestion, feeling a rush of blood to the head. Rarely seen back pain, abdomen, joints, characterized by a greater Stepney for Cialis.

All the unwanted side effects of these drugs to come, as a rule occur in mild or moderate form. For Cialis indicated a significant reduction in severity of side effects with a further extension of the application.
Both drugs absolutely contraindicated in men who are on nitrosoderzhaschie drugs (nitroglycerin in all its forms and its analogues).

Since Viagra is the flagship - the drug of first generation, and in the pharmaceutical market exists for 15 years, the accumulated information is not in her favor.
For example, in 2002, an American toxicologist G. Milman published in the journal "Annals of Pharmacotherapy" the results of scientific research about the side effects of Viagra. Patients taking Viagra, noted dizziness, disorientation, amnesia, 22 people out of 270 carried at the expense of Viagra emergence of aggression, 13 - to provoke violence, a 6 man drug called "a persistent desire to kill." Side effects of sildenafil were manifested in the chronic administration of maximum therapeutic doses (100 mg / day).
Other sources independently informed about the incompatibility of Viagra with alcohol. Mutual potentiation of the hypotensive effect of Viagra and alcohol cost the lives of many pensioners, did not observe the ban on alcohol intake.

Numerous clinical studies the effectiveness and safety of Cialis pay attention to the lack of restrictions on receiving the drug with fatty food and alcohol in a small (!) Doses, significantly increases the loyalty of patients and meet the requirements of some of them to normal life.

Thus, analysis of existing scientific and clinical data on the properties and the effect of Viagra and Cialis can opt for the latter. But we must not forget that taking a drug for impotence - not a panacea.
Some problems in the male genital area is outside the capabilities of drug therapy and require other methods of non-medicinal treatments.
Apotker
 
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Re: Viagra and Cialis: what's better?

Postby pheninfo on Thu Oct 29, 2009 12:07 pm

I know a lot of people who started use Cialis after Viagra and never returned back to Viagra.
pheninfo
 
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